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The story about the USS DEFIANT so far... (Canon)
In 2268, the Defiant responded to a distress call in the unexplored Tholian sector claimed by the Tholian Assembly. Shortly after entering the region, the Defiant's crew began experiencing sensory distortion, and insanity quickly spread throughout the ship. The ship's chief medical officer was unable to determine what was happening, and eventually the insanity induced by the phenomenon led the crew to kill each other.
At that time the Defiant was visible in the "prime universe" while in the interphase. Later, as a result of a phaser exchange between the Enterprise and the Tholians, a hole was created through the spatial interphase. The Defiant was pushed through the hole to parts unknown and in the process trapping Captain James T. Kirk between universes. Captain Kirk was eventually saved when the Enterprise, encased in a Tholian web, entered the interphase and, upon utilizing full power, was thrown clear of the region while Kirk was locked in the transporter beam.
During the 22nd century, the Tholians of the "mirror universe" created an interphasic rift by detonating a tri-cobalt warhead within the gravity well of a dead star and sent the distress call which lured the Defiant from the other side to that universe. Soon after, the Tholians took the Defiant to a drydock built into an asteroid-moon in orbit around a gas giant in the Vintaak system and began a salvage operation. This operation was reported to Commander Jonathan Archer of the ISS Enterprise NX-01 through his contacts shortly thereafter. Archer and the ISS Enterprise were eventually ordered by Admiral Black to investigate. (ENT: "In a Mirror, Darkly")
Arriving in the system, Enterprise was destroyed by a Tholian web shortly after beaming an away team over consisting of Archer, Commander T'Pol, Commander Tucker, and Sergeant Travis Mayweather. They were able to escape by restoring the partially deconstructed Defiant's shields and weapons, and destroyed the drydock.
The USS Defiant then rendezvoused with the remnants of a Terran assault fleet still engaged with rebel forces. Two Andorian battle cruisers, one Vulcan D'Kyr-type cruiser, and one Tellarite cruiser were disabling the ISS Avenger NX-09. The Defiant easily destroyed all the rebel ships except one Andorian cruiser, which Archer intentionally allowed to escape.
After seeing how Archer had treated the rebel Vulcans, and learning of the existence of the United Federation of Planets in the other universe, T'Pol and Crewman Soval tried to sabotage the Defiant with Doctor Phlox's help. When Phlox disabled main power, the Defiant was left defenseless, and Avenger, commandeered by Soval and other non-Terrans, began firing at her. The Defiant received heavy damage until Tucker was able to stop Phlox and restore main power. Archer then ordered the destruction of Avenger. The Defiant's phasers and photon torpedoes caused heavy damage to Avenger, with the second barrage of photon torpedoes breaching Avenger's warp reactor, destroying the ship with all hands.
At first, the Defiant could only reach impulse speeds because a Tholian slavemaster, a Gorn named Slar, had stolen a plasma regulator, one of the key components of the warp engines. After Archer trapped and killed the Gorn, Tucker was able to restore warp drive.
The Defiant arrived at Earth, now under the command of the self-proclaimed Empress Hoshi Sato. She ordered Admiral Gardner to surrender and stand by for instructions, or she would open fire on Earth.
The story of the ISS DEFIANT - Non-Canon... (STAR TREK - BREAKABLE)
So - the USS DEFIANT arrived finally in the 22. Century of the MU, where the Empire repaired it, give it the freaky yellow marks and renamed it into ISS DEFIANT. In my Fan-Fiction: STAR TREK - BREAKABLE it is from 2155 till 2164 the Flagship of the Imperial Starfleet. In 2164 Empress Hoshi Sato decomissioned it. Since Spring 2167 the ISS SCHARNHORST is the new Flagship of the Terran Empire.