In G1, "Prime" has a different meaning. Instead of it being a rank, it's the title of every supreme leader, and there's only one per "generation." And pretty much all of them were noble and valiant (except Nova Prime, Sentinel's predecessor). The Sentinel Prime of G1 and the Sentinel Prime of Animated don't really have anything in common besides the name and the color orange.
Well, just keep the fact that Transformers has multiple, completely unconnected timelines in its universe and you'll do fine. There's G1/Beast Wars/(begrudgingly)Beast Machines, Robots in Disguise, The Unicron Trilogy (Armada/Energon/Cybertron), Animated, the Movies, and I'm sure there's others I'm forgetting about. All are different realities and the characters merely share names and occasionally a few physical resemblances.
I like how the last two panels are descriptive of the possibility Sentinel is seeing, not the actual future. That's why the Mosaic begins in Megatron Origin, but switches to the parallel history that is The War Within by the end. This could happen, but as we now know, it doesn't.