I pretty much work every single day, except Saturdays (because that's stream day) on commissions until they are done. That usually takes till 15th-20th day of the month. Then I spend rest of the month to work on comic pages and other stuff that needs to be done so I have enough pages in stock for the first half of next month again. Rinse and repeat.
If I'm not that well prepared (or how I used to work) was that I have specific days dedicated to specific works. Sunday and Monday I work on comics. Saturdays do art stream and rest of the days commissions.
It's all big dedication and planning. But doesn't also leave you with much free time.