Are you thinking about starting a new creative endeavor that involves sequential art? Something you hope beyond family and friends will read? Have you thought about this project at all past the initial "can't wait to start working" phase?
Stop. Listen to what I am about to say. Many webcomic writers/artists make the same mistakes (myself included) by jumping straight to the "let's start drawing now" phase, bypassing the planning stage. Here are the most important items to consider before you even ink out the first strip:
Consider if there is a chance your comic will become printed. Not only do you need to consider its dpi (dots per inch), CMYK comes into play as well. It is much harder (sometimes impossible!) to retroactively make these changes instead of making the comic print-friendly beforehand. You can't enlarge a small comic that is built for the web without great quality re