I started drawing when I was 2. I practiced regularly and studied the work of the great artists and illustrators like Herge, Giles, Renee Magritte and Rick Griffin. I think to be really good you have to be borne of an infliction of obsession and have the impulsive desire to create.
For Size and Stupidity I use Photoshop; for my work I also use Photoshop, and Bryce, Daz Studio and occasionally Z-Brush (which I suck at).
What software are you using?