I would say that between the two of the Ketchum parents, Serena makes it way more evident that Lara is the legit light in her eyes, a legit piece of her soul.
If she could, Serena would spend every single second of her waking hours with Lara (and the sleeping ones too), and maybe that's the reason she got the toddler be around as much as she could, specially during the most busy times of her career.
Serena is the legit Brooklyn 99 meme "if anything happened to Lara, I will k!ll everyone in this room and then myself".
New BG techniques happened here, but most importantly I just wanted to lay some lore on why this specific 25 y/o Serena's design (I've had for a while) has some major 50's vibes. Also yes, the drama is a real-world movie reference cos I love those ∠( ᐛ 」∠)＿♥
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Pokemon ® Satoshi Taijiri / Nintendo / GameFreak
Older!Serena design, Lara Ketchum & Art ®
Oh this is precious. I can imagine the production crew trying to convince Serena that surely her daughter could be left with a caretaker until Serena informs them that she will walk right out mid-production if they keep this up. And thus, Lara becomes a permanent fixture.
Bonus points if in many bonus features we see bloopers of Lara running around in the background or showing up mid-scene to speak to mom, or in the Director's comentary they mention how Lara managed to charmt he entire cast and crew while still being a nightmare to try and film a movie around.
I'm pretty sure the TRio at least (Jessie, James, Meowth) would never try anything with her. Yeah they're villains, but they also have morals and they're more punch-clock villains at this point than anything else. I doubt they'd involve family, particuarly children.