All I do is sketch out the page according to the cleaned up thumbnails in my sketchbook, and then measure out and compose the panels digitally. What I end up with is a blank page, but with all the panels already ruled out and perfectly aligned, that I just print on Tabloid-sized paper at 10% opacity and then draw on top of. When I scan them back in, I drop them back in the template so that they're already primed for inking.
Basically, it's an easy way for me to skip the time consuming process of measuring each page and panel out with a ruler, and comes with the peace of mind knowing that there will be no additional formatting or editing to get the page from a traditional stage to a digital one.
Does... does that make sense?