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Seeing how both, Spike and Derpy are delivering Mail (though in Spike's case only in a very specific context rather than as the main profession) I sometimes think the two could have a very nice chat some time.
A giant meowing Derpy really made me laugh and Spike too was very deserving of the glory he had already sort of asked Twilight for in the episode "A Dog and Pony show": "Please, Twilight. Just give me this."