This is Dr Mrs The Monarch from The Venture Bros.on Cartoon Network's Adult Swim, I'm not familiar with this character but this sounds like a pretty fun series. I wish I had more time to give this more thought.
This is a fantastic piece I've had it in my favorites for a while but just realized that I never commented on it. Love the style and she is a perfect muse for a recreation as Dr. Mrs. The Monarch is sexy as hell especially in her super villain outfit! And the style in which you drew her she doesn't look like she does in the cartoon as you tried to give her a more real life look and I love it!!