I decided to Nuzlocke my Blue run...yeah...not going so great. I got my Butterfree Confusion (which in Blue/Red is learned at 12 instead of 10) and they immediately died, and I'm just before Mt. Moon with only three pokemon. Woo!
Dang that sucks. I'm not doing a nuzlocke run on Yellow because if that was the case I would have failed in the beginning since my rival kicked my ass.