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Bills vs. Titans odds, line, spread: Monday Night Football picks, predictions from model on 125-83 run SportsLine's model simulated Tennessee Titans vs. Buffalo Bills on MNF 10,000 times

The Buffalo Bills will look to win their fifth game in a row when they travel to Nashville to play the Tennessee Titans. Last week, the Titans defeated the lowly Jacksonville Jaguars 37-19 on the back of a 130 yard performance from star running back Derrick Henry. The win improved the Titans’ record to 3-2.

Buffalo Bills vs. Tennessee Titans NFL Week 6 Live


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Monday Night Football Live

Division leaders will square off in the NFL Week 6 edition of Monday Night Football. The Buffalo Bills hit the road to face the Tennessee Titans, with all eyes on the week's finale. Buffalo is 4-1 this season, headlined by a dominant road win over the Kansas City Chiefs last week. Tennessee is 3-2 after a 37-19 drubbing of the Jacksonville Jaguars in Week 5.

Kickoff is at 8:15 p.m. ET in Nashville. Caesars Sportsbook lists the Bills as 5.5-point road favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 53.5 in the latest Bills vs. Titans odds. Before you make any Titans vs. Bills picks or NFL predictions, you need to see what SportsLine's advanced computer simulation model has to say.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Titans, and it just released its coveted picks and predictions. You can head to SportsLine now to see model's Titans vs. Bills picks. Now, here are several NFL odds and betting lines for Bills vs. Titans:

  • Bills vs. Titans spread: Bills -5.5

  • Bills vs. Titans over-under: 53.5 points

  • Bills vs. Titans money line: Bills -260, Titans +210

  • BUF: Bills are 4-1 against the spread this season

  • TENN: Titans are 3-2 against the spread this seasonWhy Josh Allen and the Bills can cover The Bills are putting together an impressive 2021 season, headlined by owning the NFL's best point differential (plus-108) by a wide margin through five weeks. Offensively, Buffalo is No. 1 in scoring, averaging 34.4 points per game. The Bills are stellar in the ball security department with only two total turnovers and are No. 6 in first downs with 116 in five games. Led by a dual-threat option in Josh Allen, the Bills are a top-five team in rushing yards (702) and rushing touchdowns (seven). Defensively, the Bills are also excelling to this point, leading the NFL in scoring defense, total defense, turnover creation rate, net yards per pass attempt allowed, rushing touchdowns allowed and red zone defense. Buffalo also ranks in the top three in first downs allowed, passing touchdowns allowed, interceptions, rushing yards allowed, and fourth down efficiency allowed. Why Derrick Henry and the Titans can cover The Titans are a top-10 team in the NFL in scoring, averaging 26.4 points per game, and are above-average in scoring 2.23 points per offensive possession. Tennessee is also a top-10 team in total yardage, averaging 389.2 total yards per contest. Derrick Henry leads the NFL in rushing yards (640) and rushing touchdowns (seven), keying the league's No. 3 ground attack. The Titans average 4.9 yards per carry as a team, and that helps them to maintain the No. 3 mark in the NFL in first downs (127). Ball security is also paramount for quarterback Ryan Tannehill and this offense, with the Titans throwing only three interceptions (No. 8 in the NFL) and turning the ball over on only 12.5 percent of drives this season. The Titans are not elite defensively, but they have been above average in both third down defense and red zone touchdown prevention this season, giving some hope against Buffalo's high-end offense. How to make Bills vs. Titans picks SportsLine's model is leaning under on the point total, with no Bills rusher projected to reach 60 yards and the Titans projected to throw for fewer than 200 yards. The model also says one side of the spread hits in nearly 70 percent of simulations. You can only get the model's strong Bills vs. Titans picks at SportsLiine. So who wins Titans vs. Bills on Monday Night Football? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to find out which side of the Titans vs. Bills spread you need to jump on, all from the model that has crushed its NFL picks, and find out.

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