100 no's and 1 yes means YES!
Applying for jobs in the art/commercial industry is not hard you simply need to know what to do and how to do it.
(Concept artist, Illustrator, 3D artist, UI designer, Mattepainter, SFX artist, Lightingartist, Designer.)
Often when I have a back and forth with artists 'trying to break through' I ask them where they applied and with what. A common respond usually indicates they send out their personal portfolio to 1-5 places at the most. This is exactly what I did as well when I tried the first time.
Let me paint you a hypothetical situation:
You worked hard and long on your artwork and it somewhat reached at state that you're quite okay with your work. You always disliked your own work, but now not so much. Though you're still very uncertain of the quality. You see that your dream company has the job opening you were looking for, perfect! You send your portfolio website and write a nice email about how motivated you are