Big Dad n Li'l Sis

Based on actual in-game behavior, the Big Daddy would largely ignore the protestors and roughly shove aside any who actually barred his path- Unless someone did something to hurt his Little Sister or attempted to take her from him- in that case, the reaction would be *extremely* accurate.   In-Game, they're startlingly indifferent to almost everything but protecting their little sister or repairing damaged parts of Rapture, but become Juggernauts of violence the second a little sister screams.