not that remember.
sure, there were a few games from franchises or fanbases i dislike. but i never lost interest.
oh wait, does RWBY franchise can count ?
I'm not into RWBY, so I wouldn't know.
As for me, I lost interest in Mortal Kombat and Metroid.
Well, i have a friend who dropped Resident evil, just because of the story of RE5.
And he told me, that every Game, after RE4 was non-canon to him.
But if that could count... i lost interest in God of War, thanks to the 2018 reboot.