"War. War never changes. Those talking pastel-colored ponies, however... they're new."
I shouldn't have to say this, but seriously: do NOT hold a gun with your mouth. No good can come from it.
I would make a joke about being a grown man who is a fan of My Little Pony: Friendship is Magic, but I think half the internet (including myself) have done that already, so let's move on.
I was given Fallout: New Vegas and discovered the new MLP show around the same time, and while playing FO:NV with all of it's western themes, I found myself picturing Applejack as the courier.
The downed ponies are meant to be feral ghouls. I played fast and loose with their color scheme, however, for added contrast with the Mojave wasteland. That pony in the back is a Nightkin. Their cutie marks are the symbol for radioactive and a crescent moon with stars, respectively.
The gun Applejack is holding (in such a fashion that nobody should ever mimic) is the Lucky .357 magnum revolver. I chose it for its western appearance and distinct look, but I later realized it was even more appropriate that I thought given that the gun basically has its own cutie mark.
That said, I have no idea how she fires the darn thing.
EDIT: Some corrections, anti-aliased high-res version.
I did an interview with a community fanfic author Kkat back when I was working with Equestria Daily. As a few people have mentioned here, she stated that her popular fic Fallout Equestria was "inspired by a picture by Dan Shive called “Pony Vegas”." At the time of the interview I had never seen the picture. Just wanting to stop by and say great work Dan.
To the people lurking in comments, take this as a great example of how passion in an idea and love for a community can transform into a beautiful work of art that can evolve beyond your wildest expectation.
You did an inteview with kkat? Where can I find it?
I am currently reading foe on fimfiction and I noticed that it was publiced before being uploaded to fimfiction, so I am now doing some digging into how and where it started.
Have the interview here: https://www.equestriadaily.com/2016/05/equestria-daily-interviews-kkat-author.html?m=1 for ya. I also did an interview with the biggest, and better developed of the side stories "Project Horizons" author SomberPony. That, along with FoE art galleries I've made go here: https://mlpfanart.fandom.com/wiki/Allyster_Black
I wasn't expecting Fallout: New Vegas to be honest (considering how little NV references there are in FoE) but I tip my hat to you DanShive for creating this inspiring and question-rising piece of art.