At the Battle of Issus (333 BC), Darius' army was routed and the Persian king fled the field, leaving his extended family, including his mother, his wife Stateira I, his children, and many others to the mercy of Alexander. Alexander captured them but treated them with all dignity, where many a lesser conqueror would have executed them out of hand. When Alexander the Great and Hephaestion (his closest friend) went together to visit the captured Persian royal family, Sisygambis knelt to Hephaestion to plead for their lives, mistaking him for Alexander — Hephaestion was the taller, and both young men were similarly dressed. When she realized her mistake, she was acutely embarrassed, but Alexander reassured her with the words, "You were not mistaken, Mother; this man too is Alexander."
At the Battle of Gaugamela, Sisygambis and her family were kept within the baggage train behind Alexander's army. When the Persian army's Scythian cavalry broke through Alexander's forces to reach them, she allegedly refused to celebrate what appeared at first to be Persian victory.
Quintus Curtius Rufus informs that Sisygambis could never forgive her son Darius for abandoning his family at Issus. After Darius was killed shortly following his defeat at Gaugamela, Alexander sent his body to her for burial. Called upon to mourn his death, she was reported to have said, I have only one son [Alexander] and he is king of all Persia.
And speaking alexander the great REAL mother, well let just say she one nasty woman.
She came to a sad end though, and arguably both her and Alex's father were equally... troubling. Their mutual loathing for each other became legendary.