On Earth, Jene Asuna fled Earth after her father, Gale Asuna, a former Gjallerhorn mobile suit engineer, was taken in by Gjallerhorn's director of mobile suit development, Ulrich Faust. During her journey to Mars, her ship was taken over by pirates, and took Jene and raised her as human debris.
Years later, during the events of Iron-Blooded Orphans, Jene is a grown woman whose a space pirate that can use the Alaya-Vjinana system. Her pirate band’s asteroid base was attacked by Gjallerhorn resulting in the band’s destruction, leaving Jene the only survivor. She was later captured by Gjallerhorn, and then ended up on a prison ship en route to Earth. The ship was later attacked by Osiris, the resistance group leading the rebellion on Ceres and the asteroid belt. Gjallerhorn owns the asteroid belt in terms of mining minerals for Earth, and uses the inhabitants as slaves and as their labor force. Osiris’s cause is to liberate Ceres and the asteroid belt from Gjallerhorn’s oppression. Jene was then rescued by Osiris, and then taken to the asteroid belt.
Osiris’s leader, Morgan, told her that Gjallerhorn discovered a very powerful Mobile Armor, and is having Gale, her father, reconstruct it. Gjallerhorn is planning on using the Mobile Armor to destroy Osiris and bring Ceres and the asteroid belt to its knees. Jene joins Osiris to find her father, prevent the completion of the Mobile Armor with the Gundam Frame, Phenex.
During Jene’s journey to find her father and to put an end to Gjallerhorn’s rule, she’ll be making new allies along the way. Not only will she and her allies will be facing Gjallerhorn, they will also be facing a group of extremists and terrorists that sees the world as garbage, and despises humanity. This group calls itself Fenrir, led by a masked man who calls himself Imperator Tyr and pilots the Gundam Frame Marchosias.