Edward Elric vs Johnny Joestar

Fullmetal Alchemist vs JoJo's Bizarre Adventure!

After losing their brothers in a freak accident and two of their limbs due to their own arrogance, these young men would uncover a divine artifact at the center of a governmental conspiracy theory. Wielding power over a natural phenomenon (alchemy and Spin), they'd go on to battle their country's blond leader after he'd obtained divine power