Hm... I have an idea in mind, but it's a fifty/fifty between both categories. Or, as Marvel calls such things, "What If...". (Back in a day they were doing quite a lot of What If comics.)
My idea is coming from the save direction.
What If... Black Cat was an agent of S.H.I.E.L.D.?
*(if that's hard to pull out, I'll settle for Spider-Man 2099. (But not "All New-All Different" version.) )*